Niacinamide

A 12-week clinical study demonstrated a 21% improvement in fine lines along with a 14% skin tone clarity and 15% radiance improvement. Improvements were reported as early as 2 weeks. Subjects reported no stinging, itching, dryness, or tingling after 10 weeks.

In another Clinical Trial…

Subjects experienced significantly lowered oil production after 2 and 4 weeks of application with reduced clogged pores and acne breakouts.

References: J Drugs Dermatol 2016 Jul 1;15(7):863-8 combined with 0.5% retinol. Int J Dermatol. 1995 Jun;34(6):434-7. doi: 10.1111/j.1365-4362.1995.tb04449.x.